Chances are, if your parents had varicose veins, you will too. Genetics are the main cause of vein disease – but lifestyle is a factor, too. Do any of these apply to you? Age: Varicose veins usually appear between ages 30 and 70. And once they appear, they get progressively worse. Gender: Women are more likely than men to develop vein disease, especially women who have had children. Hormonal changes during pregnancy or menses can be a factor, as hormones relax vein walls. Hormone replacement therapy or birth control pills may also increase the risk. Pregnancy: Venous disease tends to worsen with multiple pregnancies. Obesity: Extra weight increases pressure within your veins, which increases the risk of developing venous disease. Long Periods of Standing: When you’re constantly on your feet in the same position for long periods of time, it inhibits efficient venous drainage and can cause stagnant flow of blood in your veins. Sedentary Lifestyle: A lifestyle without physical activity also inhibits good circulation both in your veins and arteries – including your heart. Family History: This is the best predictor of venous reflux disease. Other causes and risk factors include: Prior history of blood clots in the veins Trauma Surgery Oral contraceptives